The win allowed second-placed Liverpool to close the gap on league leaders Manchester City to two points.
Mourinho's tinkerings meant a first start of the season for midfielder Scott McTominay, playing on the right of a three-man defence, while Anthony Martial played instead of the dropped Alexis Sanchez. On this evidence, more changes may be needed when United take on Valencia in the Champions League on Tuesday.
Liverpool thrashed Atalanta 5-0, Real Madrid boosted their chances of reaching the Champions League knockout stages with a 3-2 home victory over Inter Milan and Bayern Munich came from behind to crush RB Salzburg 6-2.
Images from the FIFA World Cup qualifiers matches.
A preview of the line-up action in the English Premier League
Tottenham Hotspur brutally exposed Liverpool's defensive frailties as Harry Kane plundered two more goals in his side's 4-1 romp at Wembley on Sunday.
Following is a match by match look at the English Premier League's weekend fixtures:
A summary of Thursday night's UEFA Champions League matches.
IMAGES from the EPL matches played on Saturday
IMAGES from the English Premier League matches played on Saturday.
Huddersfield Town were left celebrating wildly after securing their Premier League safety on Wednesday with a dramatic and resilient 1-1 draw at Chelsea, a result that looks almost certain to condemn Swansea City to relegation.
Liverpool reached the Champions League final after riding their luck to contain a fired-up AS Roma in a 4-2 defeat at the Stadio Olimpico on Wednesday that sent them through 7-6 on aggregate.
Klopp has led Liverpool to back-to-back Champions League finals but is adamant that their impressive recent track record does not make them the title favourites.
News of all that transpired on and off the football field.
Manchester United and Chelsea secured places in the Champions League with wins on the final day of the Premier League season while Watford and Bournemouth were relegated along with bottom club Norwich City.
A round-up of Saturday's matches in the English Premier League.
A round-up of Wednesday's action in the UEFA Champions League.
The win moved Spurs up to third but unbeaten Manchester City still looked in a class of their own at the top as Leroy Sane scored twice in a 4-0 stroll over West Ham United.
Manchester City went 11 points clear with a record 14th consecutive Premier League win in an entertaining derby against Manchester United at Old Trafford.
Manchester City set a new top-flight record of 15 consecutive wins as their seemingly unstoppable march towards the English Premier League title continued with a 4-0 romp at bottom club Swansea City.
IMAGES from Premier League matches played on Sunday.
Inter Milan's aversion to Europa League football continued with a 3-1 defeat at Sparta Prague, while AS Roma ended a continental hoodoo stretching back seven games with a 4-0 home win over Romanian side FC Astra on Thursday.
Images from the English Premier League matches played on Saturday
News of all that's transpired on and off the football field
A round-up of the action in the English Premier League on Monday.
Watford climbed into the top four of the Premier League after Tom Cleverley's 92nd-minute goal gave them a 2-1 victory over Arsenal at Vicarage Road on Saturday.
News of all that's transpired on and off the football field
Images from the Champions League matches played on Tuesday
IMAGES from the English Premier League matches played on Sunday.
Real Madrid's Cristiano Ronaldo was the scourge of AS Roma again as he inspired the hosts to a 2-0 win and a place in the Champions League quarter-finals on Tuesday, scoring and setting up a goal Rodriguez to seal a 4-0 aggregate victory.
Ibrahimovic was forced off with a muscle problem with 11 minutes remaining, and the Swede was pictured sitting on the bench with an ice pack strapped to the back of his left leg.
While Lyon rallied to hold Leipzig 2-2 after a Memphis Depay strike, it was the English clubs who made a mark on the night. Liverpool and Chelsea moved into the last 16 with contrasting wins and now all four English clubs, including Manchester City and Tottenham Hotspur, are in the Champions League knockouts this season.
News of all that's transpired on and off the football field
Images from the English Premier League matches played on Saturday.
Images from the English Premier League matches played on Wednesday.
A round-up of Wednesday's night's UEFA Chmpions League matches.
IMAGES from the English Premier League matches played on Saturday.
La Liga champions Real Madrid beat Getafe 3-1 on Saturday with a goal from Gareth Bale and two strikes from Cristiano Ronaldo to go 12 points behind leaders Barcelona and warm up for next week's Champions League game at Paris St Germain.
City, who have a 16-point lead, can win the Premier League title with a victory over Jose Mourinho's side at the Etihad Stadium on Saturday, but after their 3-0 loss to Liverpool in the Champions League on Wednesday, Guardiola said the players needed a lift.
Ahead of their high-profile clash on Saturday, check out the five standout clashes between Arsenal and Chelsea.
